Mechanisms of palmitate-induced lipotoxicity in osteocytes
نویسندگان
چکیده
منابع مشابه
Ameliorative Role of Palmitoleic Acid on Palmitate Induced Lipotoxicity in the Rat Cardiomyocytes
Background: Co-supplementation of unsaturated fatty acids (FAs) with saturated FAs may decrease the adverse effects of saturated FA-induced lipotoxicity. The objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. Methods: Ce...
متن کاملameliorative role of palmitoleic acid on palmitate induced lipotoxicity in the rat cardiomyocytes
background: co-supplementation of unsaturated fatty acids (fas) with saturated fas may decrease the adverse effects of saturated fa-induced lipotoxicity. the objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. methods: cells...
متن کاملCytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes.
It is well known that Phellinus linteus, which produces hispidin and its derivatives, possesses antioxidant activities. In this study, we investigated whether hispidin has protective effects on palmitate-induced oxidative stress in C2C12 skeletal muscle cells. Our results showed that palmitate treatment in C2C12 myotubes increased ROS generation and cell death as compared with the control. Howe...
متن کاملMechanisms of palmitate-induced cell death in human osteoblasts
Lipotoxicity is an overload of lipids in non-adipose tissues that affects function and induces cell death. Lipotoxicity has been demonstrated in bone cells in vitro using osteoblasts and adipocytes in coculture. In this condition, lipotoxicity was induced by high levels of saturated fatty acids (mostly palmitate) secreted by cultured adipocytes acting in a paracrine manner. In the present study...
متن کاملBaicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1
OBJECTIVE β-Cell dysfunction plays a central role in the pathogenesis of type 2 diabetes (T2D), and the identification of novel approaches to improve β-cell function is essential to treat this disease. Baicalein, a flavonoid originally isolated from the root of Scutellaria Baicalensis, has been shown to have beneficial effects on β-cell function. Here, the authors investigated the molecular mec...
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ژورنال
عنوان ژورنال: Bone
سال: 2019
ISSN: 8756-3282
DOI: 10.1016/j.bone.2019.06.016